Publications

 View full listing of publications by this faculty member.

• Mechanisms Regulating Mitochondrial Transfer in Human Corneal Epithelial Cells.
  Pal-Ghosh S, Karpinski BA, Datta-Majumdar H, Datta S, Dimri S, Hally J, Wehmeyer H, Stepp MA. Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):10. doi: 10.1167/iovs.65.13.10.PMID: 39504055 Free PMC article.
• ROCK Inhibitor Enhances Neurite Outgrowth In Vitro and Corneal Sensory Nerve Reinnervation In Vivo.
  Karpinski BA, Pal-Ghosh S, Datta-Majumdar H, Dimri S, Datta S, Stepp MA. Invest Ophthalmol Vis Sci. 2024 Oct 1;65(12):31. doi: 10.1167/iovs.65.12.31.PMID: 39436373 Free PMC article.
• Mouse Corneal Immune Cell Heterogeneity Revealed by Single-Cell RNA Sequencing.
  Yaman E, Heyer N, de Paiva CS, Stepp MA, Pflugfelder SC, Alam J.Invest Ophthalmol Vis Sci. 2024 Oct 1;65(12):29. doi: 10.1167/iovs.65.12.29.PMID: 39432400 Free PMC article.
• Immunoregulatory Properties of Immune Cells that Associate with the Lens Capsule Surface during Acute and Resolution Phases of Experimental Autoimmune Uveitis.
  Le PM, Mattapallil MJ, Caspi RR, Stepp MA, Menko AS.Am J Pathol. 2024 Nov;194(11):2194-2211. doi: 10.1016/j.ajpath.2024.07.021. Epub 2024 Aug 17.PMID: 39159867 Free article.
• Single cell analysis of short-term dry eye induced changes in cornea immune cell populations.
  Alam J, Yaman E, Silva GCV, Chen R, de Paiva CS, Stepp MA, Pflugfelder SC.Front Med (Lausanne). 2024 Mar 15;11:1362336. doi: 10.3389/fmed.2024.1362336. eCollection 2024.PMID: 38560382 Free PMC article.
• EDITORIAL: Special issue on the Tear Film and the Ocular Surface.
  Suárez-Cortés T, Stepp MA. Exp Eye Res. 2024 Jan;238:109705. doi: 10.1016/j.exer.2023.109705. Epub 2023 Nov 7.PMID: 37944850 No abstract available.
• Conditional deletion of CD25 in the corneal epithelium reveals sex differences in barrier disruption.
  Abu-Romman A, Scholand KK, Pal-Ghosh S, Yu Z, Kelagere Y, Yazdanpanah G, Kao WW, Coulson-Thomas VJ, Stepp MA, de Paiva CS.Ocul Surf. 2023 Oct;30:57-72. doi: 10.1016/j.jtos.2023.07.008. Epub 2023 Jul 27.PMID: 37516317 Free PMC article.
• Immune Cells Localize to Sites of Corneal Erosions in C57BL/6 Mice.
  Le PM, Pal-Ghosh S, Menko AS, Stepp MA. Biomolecules. 2023 Jun 29;13(7):1059. doi: 10.3390/biom13071059.PMID: 37509096 Free PMC article.
• Molecular mechanisms regulating wound repair: Evidence for paracrine signaling from corneal epithelial cells to fibroblasts and immune cells following transient epithelial cell treatment with Mitomycin C.
  Pal-Ghosh S, Karpinski BA, Datta Majumdar H, Ghosh T, Thomasian J, Brooks SR, Sawaya AP, Morasso MI, Scholand KK, de Paiva CS, Galletti JG, Stepp MA. Exp Eye Res. 2023 Feb;227:109353. doi: 10.1016/j.exer.2022.109353. Epub 2022 Dec 17.PMID: 36539051 Free PMC article.
• Uveitis-mediated immune cell invasion through the extracellular matrix of the lens capsule.
  DeDreu J, Pal-Ghosh S, Mattapallil MJ, Caspi RR, Stepp MA, Menko AS.FASEB J. 2022 Jan;36(1):e21995. doi: 10.1096/fj.202101098R.PMID: 34874579 Free PMC article.
• Immune responses to injury and their links to eye disease.
  Stepp MA, Menko AS.Transl Res. 2021 Oct;236:52-71. doi: 10.1016/j.trsl.2021.05.005. Epub 2021 May 27.PMID: 34051364 Free PMC article. Review.
• Type 2 immunity induced by bladder extracellular matrix enhances corneal wound healing.
  Wang X, Chung L, Hooks J, Maestas DR Jr, Lebid A, Andorko JI, Huleihel L, Chin AF, Wolf M, Remlinger NT, Stepp MA, Housseau F, Elisseeff JH.Sci Adv. 2021 Apr 16;7(16):eabe2635. doi: 10.1126/sciadv.abe2635. Print 2021 Apr.PMID: 33863719 Free PMC article.
• Identification of presumed corneal neuromas and microneuromas using laser-scanning in vivo confocal microscopy: a systematic review.
  Chinnery HR, Rajan R, Jiao H, Wu M, Zhang AC, De Silva MEH, Makrai E, Stepp MA, Di Girolamo N, Downie LE.Br J Ophthalmol. 2022 Jun;106(6):765-771. doi: 10.1136/bjophthalmol-2020-318156. Epub 2021 Feb 10.PMID: 33568390 Free PMC article.
• Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers.
  Bargagna-Mohan P, Schultz G, Rheaume B, Trakhtenberg EF, Robson P, Pal-Ghosh S, Stepp MA, Given KS, Macklin WB, Mohan R.J Neurosci Res. 2021 Mar;99(3):731-749. doi: 10.1002/jnr.24757. Epub 2020 Nov 16.PMID: 33197966 Free PMC article.
• Combination therapy of cold atmospheric plasma (CAP) with temozolomide in the treatment of U87MG glioblastoma cells.
  Gjika E, Pal-Ghosh S, Kirschner ME, Lin L, Sherman JH, Stepp MA, Keidar M.Sci Rep. 2020 Oct 5;10(1):16495. doi: 10.1038/s41598-020-73457-7.PMID: 33020527 Free PMC article.
• Diurnal Control of Sensory Axon Growth and Shedding in the Mouse Cornea.
  Pal-Ghosh S, Tadvalkar G, Karpinski BA, Stepp MA. Invest Ophthalmol Vis Sci. 2020 Sep 1;61(11):1. doi: 10.1167/iovs.61.11.1.PMID: 32870244 Free PMC article.
• The impact of euthanasia and enucleation on mouse corneal epithelial axon density and nerve terminal morphology.
  Tadvalkar G, Pal-Ghosh S, Pajoohesh-Ganji A, Stepp MA. Ocul Surf. 2020 Oct;18(4):821-828. doi: 10.1016/j.jtos.2020.07.021. Epub 2020 Aug 13.PMID: 32798735 Free PMC article.
• Integrin: Basement membrane adhesion by corneal epithelial and endothelial cells.
  McKay TB, Schlötzer-Schrehardt U, Pal-Ghosh S, Stepp MA. Exp Eye Res. 2020 Sep;198:108138. doi: 10.1016/j.exer.2020.108138. Epub 2020 Jul 23.PMID: 32712184 Free PMC article. Review.
• Parity Attenuates Intraepithelial Corneal Sensory Nerve Loss in Female Mice.
  Stepp MA, Pal-Ghosh S, Tadvalkar G, de Paiva CS.Int J Mol Sci. 2020 Jul 21;21(14):5172. doi: 10.3390/ijms21145172.PMID: 32708332 Free PMC article.
• An immune response to the avascular lens following wounding of the cornea involves ciliary zonule fibrils.
  DeDreu J, Bowen CJ, Logan CM, Pal-Ghosh S, Parlanti P, Stepp MA, Menko AS.FASEB J. 2020 Jul;34(7):9316-9336. doi: 10.1096/fj.202000289R. Epub 2020 May 25.PMID: 32452112 Free PMC article.
• Axonal debris accumulates in corneal epithelial cells after intraepithelial corneal nerves are damaged: A focused Ion Beam Scanning Electron Microscopy (FIB-SEM) study.
  Parlanti P, Pal-Ghosh S, Williams A, Tadvalkar G, Popratiloff A, Stepp MA. Exp Eye Res. 2020 May;194:107998. doi: 10.1016/j.exer.2020.107998. Epub 2020 Mar 21.PMID: 32209319 Free PMC article.
• Corneal Epithelial "Neuromas": A Case of Mistaken Identity?
  Stepp MA, Pal-Ghosh S, Downie LE, Zhang AC, Chinnery HR, Machet J, Di Girolamo N.Cornea. 2020 Jul;39(7):930-934. doi: 10.1097/ICO.0000000000002294.PMID: 32118667 Free PMC article. Review.
• Transient Mitomycin C-treatment of human corneal epithelial cells and fibroblasts alters cell migration, cytokine secretion, and matrix accumulation.
  Pal-Ghosh S, Tadvalkar G, Lieberman VR, Guo X, Zieske JD, Hutcheon A, Stepp MA. Sci Rep. 2019 Sep 25;9(1):13905. doi: 10.1038/s41598-019-50307-9.PMID: 31554858 Free PMC article.
• Fibrosis: Shared Lessons From the Lens and Cornea.
  Menko AS, Walker JL, Stepp MA. Anat Rec (Hoboken). 2020 Jun;303(6):1689-1702. doi: 10.1002/ar.24088. Epub 2019 Mar 18.PMID: 30768772 Free PMC article. Review.
• Desmin deficiency is not sufficient to prevent corneal fibrosis.
  Pietraszkiewicz A, Hampton C, Caplash S, Lei L, Capetanaki Y, Tadvalkar G, Pal-Ghosh S, Stepp MA, Bargagna-Mohan P, Mohan R.Exp Eye Res. 2019 Mar;180:155-163. doi: 10.1016/j.exer.2018.12.019. Epub 2018 Dec 24.PMID: 30590024 Free PMC article.
• Stepp MA, Pal-Ghosh S, Tadvalkar G, Williams A, Pflugfelder SC, de Paiva CS. Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice.Exp Eye Res. 2018 Apr;169:91-98. doi: 10.1016/j.exer.2018.01.024. Epub 2018 Jan 31.PMID: 29407221, PMCID: PMC: 29407221
• Kaplan N, Ventrella R, Peng H, Pal-Ghosh S, Arvanitis C, Rappoport JZ, Mitchell BJ, Stepp MA, Lavker RM, Getsios S. EphA2/Ephrin-A1 Mediate Corneal Epithelial Cell Compartmentalization via ADAM10 Regulation of EGFR Signaling. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):393-406. doi: 10.1167/iovs.17-22941.PMID: 2935135, PMCID: PMC: 2935135
• Gjika E, Pal-Ghosh S, Tang A, Kirschner M, Tadvalkar G, Canady J, Stepp MA, Keidar M. Adaptation of Operational Parameters of Cold Atmospheric Plasma for in Vitro Treatment of Cancer Cells. ACS Appl Mater Interfaces. 2018 Mar 21;10(11):9269-9279. doi: 10.1021/acsami.7b18653. Epub 2018 Mar 6.PMID: 29473408, PMCID: PMC: 29473408
• Pal-Ghosh S, Tadvalkar G, Stepp MA. Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):4959-4975. doi: 10.1167/iovs.17-21531.PMID:2897336, PMCID:PMC2897336
• Stepp MA, Tadvalkar G, Hakh R, Pal-Ghosh S. Corneal epithelial cells function as surrogate Schwann cells for their sensory nerves. Glia. 2017; 65(6):851-863. NIHMSID: NIHMS828394 PubMed [journal] PMID: 27878997, PMCID: PMC5395310
• Pal-Ghosh S, Pajoohesh-Ganji A, Tadvalkar G, Kyne BM, Guo X, Zieske JD, Stepp MA. Topical Mitomycin-C enhances subbasal nerve regeneration and reduces erosion frequency in the debridement wounded mouse cornea. Experimental eye research. 2016; 146:361-9. NIHMSID: NIHMS730540 PubMed [journal] PMID: 26332224, PMCID:PMC4775450
• Pajoohesh-Ganji A, Pal-Ghosh S, Tadvalkar G, Stepp MA. K14 + compound niches are present on the mouse cornea early after birth and expand after debridement wounds. Developmental dynamics : an official publication of the American Association of Anatomists. 2016; 245(2):132-43. NIHMSID: NIHMS734678 PubMed [journal] PMID: 26515029, PMCID: PMC4715603
• Pajoohesh-Ganji A, Pal-Ghosh S, Tadvalkar G, Kyne BM, Saban DR, Stepp MA. Partial denervation of sub-basal axons persists following debridement wounds to the mouse cornea. Laboratory investigation; a journal of technical methods and pathology. 2015; 95(11):1305-18. NIHMSID: NIHMS703215 PubMed [journal] PMID: 26280222, PMCID: PMC4626298
• Stepp MA, Pal-Ghosh S, Tadvalkar G, Pajoohesh-Ganji A. Syndecan-1 and Its Expanding List of Contacts. Advances in wound care. 2015; 4(4):235-249. PubMed [journal] PMID: 25945286, PMCID: PMC4397989
• Pajoohesh-Ganji A, Burns MP, Pal-Ghosh S, Tadvalkar G, Hokenbury NG, Stepp MA, Faden AI. Inhibition of amyloid precursor protein secretases reduces recovery after spinal cord injury. Brain research. 2014; 1560:73-82. NIHMSID: NIHMS576081 PubMed [journal] PMID: 24630972, PMCID: PMC4129635
• Pal-Ghosh S, Pajoohesh-Ganji A, Menko AS, Oh HY, Tadvalkar G, Saban DR, Stepp MA. Cytokine deposition alters leukocyte morphology and initial recruitment of monocytes and γδT cells after corneal injury. Investigative ophthalmology & visual science. 2014; 55(4):2757-65. PubMed [journal] PMID: 24677104, PMCID: PMC4004424
• Stepp MA, Zieske JD, Trinkaus-Randall V, Kyne BM, Pal-Ghosh S, Tadvalkar G, Pajoohesh-Ganji A. Wounding the cornea to learn how it heals. Experimental eye research. 2014; 121:178-93. NIHMSID: NIHMS578816 PubMed [journal] PMID: 24607489, PMCID: PMC4072315
• Menko AS, Bleaken BM, Libowitz AA, Zhang L, Stepp MA, Walker JL. A central role for vimentin in regulating repair function during healing of the lens epithelium. Molecular biology of the cell. 2014; 25(6):776-90. PubMed [journal] PMID: 24478454, PMCID: PMC3952848
• Keidar M, Shashurin A, Volotskova O, Stepp M, Srinivasan P, Sandler A, Trink B. Cold atmospheric plasma in cancer therapy. Physics of Plasmas. 2013; 20(5):057101. My Bibliography [journal]
• Pajoohesh-Ganji A, Pal-Ghosh S, Tadvalkar G, Stepp MA. Corneal goblet cells and their niche: implications for corneal stem cell deficiency. Stem cells (Dayton, Ohio). 2012; 30(9):2032-43. NIHMSID: NIHMS398921 PubMed [journal] PMID: 22821715, PMCID: PMC3635098
• Padmakumar VC, Speer K, Pal-Ghosh S, Masiuk KE, Ryscavage A, Dengler SL, Hwang S, Edwards JC, Coppola V, Tessarollo L, Stepp MA, Yuspa SH. Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice. The American journal of pathology. 2012; 181(1):74-84. PubMed [journal] PMID: 22613027, PMCID: PMC3388159
• Volotskova O, Hawley TS, Stepp MA, Keidar M. Targeting the cancer cell cycle by cold atmospheric plasma. Scientific reports. 2012; 2:636. PubMed [journal] PMID: 22957140, PMCID: PMC3434394
• Pal-Ghosh S, Pajoohesh-Ganji A, Tadvalkar G, Stepp MA. Removal of the basement membrane enhances corneal wound healing. Experimental eye research. 2011; 93(6):927-36. NIHMSID: NIHMS336272 PubMed [journal] PMID: 22067129, PMCID: PMC3443627
• Blanco-Mezquita JT, Hutcheon AE, Stepp MA, Zieske JD. αVβ6 integrin promotes corneal wound healing. Investigative ophthalmology & visual science. 2011; 52(11):8505-13. PubMed [journal] PMID: 21960555, PMCID: PMC3208190
• Pal-Ghosh S, Blanco T, Tadvalkar G, Pajoohesh-Ganji A, Parthasarathy A, Zieske JD, Stepp MA. MMP9 cleavage of the β4 integrin ectodomain leads to recurrent epithelial erosions in mice. Journal of cell science. 2011; 124(Pt 15):2666-75. PubMed [journal] PMID: 21750188, PMCID: PMC3138707
• Velasco J, Li J, DiPietro L, Stepp MA, Sandy JD, Plaas A. Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling. The Journal of biological chemistry. 2011; 286(29):26016-27. PubMed [journal] PMID: 21566131, PMCID: PMC3138253
• Stepp MA, Daley WP, Bernstein AM, Pal-Ghosh S, Tadvalkar G, Shashurin A, Palsen S, Jurjus RA, Larsen M. Syndecan-1 regulates cell migration and fibronectin fibril assembly. Experimental cell research. 2010; 316(14):2322-39. NIHMSID: NIHMS213918 PubMed [journal] PMID: 20580707, PMCID: PMC3141227
• Stepp MA, Pal-Ghosh S, Tadvalkar G, Rajjoub L, Jurjus RA, Gerdes M, Ryscavage A,  Cataisson C, Shukla A, Yuspa SH. Loss of syndecan-1 is associated with malignant conversion in skin carcinogenesis. Molecular carcinogenesis. 2010; 49(4):363-73. NIHMSID: NIHMS469026 PubMed [journal] PMID: 20082322, PMCID: PMC3653623
• Singh P, Chen C, Pal-Ghosh S, Stepp MA, Sheppard D, Van De Water L. Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing. The Journal of investigative dermatology. 2009; 129(1):217-28. NIHMSID: NIHMS472637 PubMed [journal] PMID: 18633440, PMCID: PMC3681306
• Pal-Ghosh S, Tadvalkar G, Jurjus RA, Zieske JD, Stepp MA. BALB/c and C57BL6 mouse strains vary in their ability to heal corneal epithelial debridement wounds. Experimental eye research. 2008; 87(5):478-86. NIHMSID: NIHMS78366 PubMed [journal] PMID: 18809399, PMCID: PMC2654715
• Mayo C, Ren R, Rich C, Stepp MA, Trinkaus-Randall V. Regulation by P2X7: epithelial migration and stromal organization in the cornea. Investigative ophthalmology & visual science. 2008; 49(10):4384-91. NIHMSID: NIHMS77322 PubMed [journal] PMID: 18502993, PMCID: PMC2605938
• Jurjus RA, Liu Y, Pal-Ghosh S, Tadvalkar G, Stepp MA. Primary dermal fibroblasts derived from sdc-1 deficient mice migrate faster and have altered alphav integrin function. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2008; 16(5):649-60. NIHMSID: NIHMS469027 PubMed [journal] PMID: 19128260, PMCID: PMC3664453
• Tripathi BK, Stepp MA, Gao CY, Zelenka PS. The Cdk5 inhibitor olomoucine promotes corneal debridement wound closure in vivo. Molecular vision. 2008; 14:542-9. PubMed [journal] PMID: 18385789, PMCID: PMC2274924
• Stepp MA, Liu Y, Pal-Ghosh S, Jurjus RA, Tadvalkar G, Sekaran A, Losicco K, Jiang L, Larsen M, Li L, Yuspa SH. Reduced migration, altered matrix and enhanced TGFbeta1 signaling are signatures of mouse keratinocytes lacking Sdc1. Journal of cell science. 2007; 120(Pt 16):2851-63. PubMed [journal] PMID: 17666434
• Vanhoutte D, Schellings MW, Götte M, Swinnen M, Herias V, Wild MK, Vestweber D, Chorianopoulos E, Cortés V, Rigotti A, Stepp MA, Van de Werf F, Carmeliet P, Pinto YM, Heymans S. Increased expression of syndecan-1 protects against cardiac dilatation and dysfunction after myocardial infarction. Circulation. 2007; 115(4):475-82. PubMed [journal] PMID: 17242279
• Stepp MA. Corneal integrins and their functions. Experimental eye research. 2006; 83(1):3-15. PubMed [journal] PMID: 16580666
• Pajoohesh-Ganji A, Pal-Ghosh S, Simmens SJ, Stepp MA. Integrins in slow-cycling corneal epithelial cells at the limbus in the mouse. Stem cells (Dayton, Ohio).2006; 24(4):1075-86. PubMed [journal] PMID: 16282441
• Hutcheon AE, Guo XQ, Stepp MA, Simon KJ, Weinreb PH, Violette SM, Zieske JD. Effect of wound type on Smad 2 and 4 translocation. Investigative ophthalmology & visual science. 2005; 46(7):2362-8. PubMed [journal] PMID: 15980223
• Pajoohesh-Ganji A, Stepp MA. In search of markers for the stem cells of the corneal epithelium. Biology of the cell. 2005; 97(4):265-76. PubMed [journal] PMID: 15762848
• Stepp MA, Zieske JD. The corneal epithelial stem cell niche. The ocular surface. 2005; 3(1):15-26. PubMed [journal] PMID: 17131002
• Singh P, Reimer CL, Peters JH, Stepp MA, Hynes RO, Van De Water L. The spatial and temporal expression patterns of integrin alpha9beta1 and one of its ligands,  the EIIIA segment of fibronectin, in cutaneous wound healing. The Journal of investigative dermatology. 2004; 123(6):1176-81. PubMed [journal] PMID: 15610531
• Gao CY, Stepp MA, Fariss R, Zelenka P. Cdk5 regulates activation and localization of Src during corneal epithelial wound closure. Journal of cell science. 2004; 117(Pt 18):4089-98. PubMed [journal] PMID: 15280426
• Pajoohesh-Ganji A, Ghosh SP, Stepp MA. Regional distribution of alpha9beta1 integrin within the limbus of the mouse ocular surface. Developmental dynamics :  an official publication of the American Association of Anatomists. 2004; 230(3):518-28. PubMed [journal] PMID: 15188436
• Pal-Ghosh S, Pajoohesh-Ganji A, Brown M, Stepp MA. A mouse model for the study of recurrent corneal epithelial erosions: alpha9beta1 integrin implicated in progression of the disease. Investigative ophthalmology & visual science. 2004; 45(6):1775-88. PubMed [journal] PMID: 15161840
• Tomczuk M, Takahashi Y, Huang J, Murase S, Mistretta M, Klaffky E, Sutherland A, Bolling L, Coonrod S, Marcinkiewicz C, Sheppard D, Stepp MA, White JM. Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3. Experimental cell research. 2003; 290(1):68-81. PubMed [journal] PMID: 14516789
• Stepp MA, Gibson HE, Gala PH, Iglesia DD, Pajoohesh-Ganji A, Pal-Ghosh S, Brown M, Aquino C, Schwartz AM, Goldberger O, Hinkes MT, Bernfield M. Defects in keratinocyte activation during wound healing in the syndecan-1-deficient mouse. Journal of cell science. 2002; 115(Pt 23):4517-31. PubMed [journal] PMID: 12414997
• Belkin AM, Stepp MA. Integrins as receptors for laminins. Microscopy research and technique. 2000; 51(3):280-301. PubMed [journal] PMID: 11054877
• Sta Iglesia DD, Stepp MA. Disruption of the basement membrane after corneal débridement. Investigative ophthalmology & visual science. 2000; 41(5):1045-53. PubMed [journal] PMID: 10752940
• Sta Iglesia DD, Gala PH, Qiu T, Stepp MA. Integrin expression during epithelial migration and restratification in the tenascin-C-deficient mouse cornea. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2000; 48(3):363-76. PubMed [journal] PMID: 10681390